Which statement is true about Rh compatibility in transfusions?

Which statement is true about Rh compatibility in transfusions?

• A. Rh-negative blood is given to Rh-negative patients
• B. Rh-negative blood can be given to Rh-positive patients
• C. Rh-positive blood can be given to Rh-negative patients
• D. Rh-positive blood is never given to Rh-positive patients

Answer: (A)

Rh compatibility centers on whether red blood cells carry the D antigen. People who are Rh-negative lack this antigen, so if they receive Rh-positive blood, their immune system can recognize the D antigen as foreign and make anti-D antibodies. Those antibodies can then cause a reaction if the person is exposed to Rh-positive blood again in the future. To prevent this sensitization, the safest and most consistent practice is to transfuse Rh-negative patients with Rh-negative blood. Rh-positive blood can be given to Rh-positive recipients because their immune system already tolerates the D antigen. The other options would risk sensitization or are simply not necessary for someone who is Rh-positive.

Rh compatibility centers on whether red blood cells carry the D antigen. People who are Rh-negative lack this antigen, so if they receive Rh-positive blood, their immune system can recognize the D antigen as foreign and make anti-D antibodies. Those antibodies can then cause a reaction if the person is exposed to Rh-positive blood again in the future. To prevent this sensitization, the safest and most consistent practice is to transfuse Rh-negative patients with Rh-negative blood. Rh-positive blood can be given to Rh-positive recipients because their immune system already tolerates the D antigen. The other options would risk sensitization or are simply not necessary for someone who is Rh-positive.